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1994 1
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56 results

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Page 1
Genomics and hearing impairment.
Keats BJ, Berlin CI. Keats BJ, et al. Genome Res. 1999 Jan;9(1):7-16. Genome Res. 1999. PMID: 9927480 Free article. Review.
The genes that have been identified encode diaphanous (HDIA1), alpha-tectorin (TECTA), the transcription factor POU4F3, connexin 26 (GJB2), and two unconventional myosins (MYO7A and MYO15), and four novel proteins (PDS, COCH, DFNA5, DFNB9). ...Additionally, the mouse ortho …
The genes that have been identified encode diaphanous (HDIA1), alpha-tectorin (TECTA), the transcription factor POU4F3, connexin 26 (GJB2 …
Analysis of Epidermal Growth Factor Receptor Related Gene Expression Changes in a Cellular and Animal Model of Parkinson's Disease.
Kim IS, Koppula S, Park SY, Choi DK. Kim IS, et al. Int J Mol Sci. 2017 Feb 16;18(2):430. doi: 10.3390/ijms18020430. Int J Mol Sci. 2017. PMID: 28212331 Free PMC article.
We employed transcriptome analysis of epidermal growth factor receptor related gene expression changes in cellular and animal models of Parkinson's disease (PD). We used a well-known Parkinsonian toxin 1-methyl-4-phenylpyridine (MPP+) to induce neuronal apopt …
We employed transcriptome analysis of epidermal growth factor receptor related gene expression changes in cellular and animal mode …
ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness.
Liu Y, Pandey PR, Sharma S, Xing F, Wu K, Chittiboyina A, Wu SY, Tyagi A, Watabe K. Liu Y, et al. Breast Cancer Res Treat. 2019 May;175(1):77-90. doi: 10.1007/s10549-018-05126-3. Epub 2019 Feb 6. Breast Cancer Res Treat. 2019. PMID: 30725231 Free PMC article.
ID2 also plays a pivotal role in survival of the aggressive cancer cells. In addition, we identified INHBA and GJB2 as key regulators for the transition of benign DCIS to aggressive phenotype. ...CONCLUSION: Our results indicate that ID2 is a key driver of DCIS formation a …
ID2 also plays a pivotal role in survival of the aggressive cancer cells. In addition, we identified INHBA and GJB2 as key regulators …
Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness.
Nickel R, Forge A. Nickel R, et al. Curr Opin Otolaryngol Head Neck Surg. 2008 Oct;16(5):452-7. doi: 10.1097/MOO.0b013e32830e20b0. Curr Opin Otolaryngol Head Neck Surg. 2008. PMID: 18797288 Review.
PURPOSE OF REVIEW: Mutations in GJB2 and GJB6, the genes encoding the gap-junction proteins connexin 26 and connexin 30, are the most common cause of autosomal recessive nonsyndromic deafness in many populations across the world. ...Rather than being mere conduits for the …
PURPOSE OF REVIEW: Mutations in GJB2 and GJB6, the genes encoding the gap-junction proteins connexin 26 and connexin 30, are the most …
Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates.
Thakur P, DeBo R, Dugan GO, Bourland JD, Michalson KT, Olson JD, Register TC, Kock ND, Cline JM. Thakur P, et al. Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):249-259. doi: 10.1016/j.ijrobp.2021.03.058. Epub 2021 Apr 20. Int J Radiat Oncol Biol Phys. 2021. PMID: 33848608 Free PMC article.
RNA sequencing analysis of lung tissue revealed SERPINA3, ATP12A, GJB2, CLDN10, TOX3, and LPA as top dysregulated transcripts in irradiated animals. ...
RNA sequencing analysis of lung tissue revealed SERPINA3, ATP12A, GJB2, CLDN10, TOX3, and LPA as top dysregulated transcripts in irra …
Mouse models for human hereditary deafness.
Leibovici M, Safieddine S, Petit C. Leibovici M, et al. Curr Top Dev Biol. 2008;84:385-429. doi: 10.1016/S0070-2153(08)00608-X. Curr Top Dev Biol. 2008. PMID: 19186249 Review.
Yet, limited information regarding the underlying pathogenic mechanisms can be derived from hearing tests in deaf patients. This chapter describes the success of mouse models in the elucidation of some pathophysiological processes in the auditory sensory organ, the cochlea …
Yet, limited information regarding the underlying pathogenic mechanisms can be derived from hearing tests in deaf patients. This chapter des …
Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease.
Laird DW. Laird DW. J Biol Chem. 2008 Feb 8;283(6):2997-3001. doi: 10.1074/jbc.R700041200. Epub 2007 Dec 18. J Biol Chem. 2008. PMID: 18089569 Free article. Review.
Frequently, these mutations are autosomal recessive, whereas in other cases, autosomal dominant mutations manifest as disease. Given the broad and overlapping distribution of connexins in a wide arrangement of tissues, it is hard to predict where connexin-linked diseases w …
Frequently, these mutations are autosomal recessive, whereas in other cases, autosomal dominant mutations manifest as disease. Given …
MicroRNA 181a-2-3p Alleviates the Apoptosis of Renal Tubular Epithelial Cells via Targeting GJB2 in Sepsis-Induced Acute Kidney Injury.
Yi HX, Jiang SY, Yu LH, Chen K, Yang ZX, Wu Q. Yi HX, et al. Mol Cell Biol. 2021 Jun 23;41(7):e0001621. doi: 10.1128/MCB.00016-21. Epub 2021 Jun 23. Mol Cell Biol. 2021. PMID: 33875577 Free PMC article.
Further, the dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were carried out, which confirmed that GJB2 was a target of miR-181a-2-3p, and overexpression of GJB2 reversed the anti-inflammatory and antiapoptotic effects of miR-181a-2-3p mimic …
Further, the dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were carried out, which confirmed that GJB2 was a …
Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models.
Hoang Dinh E, Ahmad S, Chang Q, Tang W, Stong B, Lin X. Hoang Dinh E, et al. Brain Res. 2009 Jun 24;1277:52-69. doi: 10.1016/j.brainres.2009.02.008. Epub 2009 Feb 20. Brain Res. 2009. PMID: 19230829 Free PMC article. Review.
In vitro studies of reconstituted GJs in cell lines have yielded surprisingly heterogeneous mechanisms of dysfunction caused by various Cx mutations. Availability of multiple lines of Cx-mutant mouse models has provided some insight into the pathogenesis processes in the c …
In vitro studies of reconstituted GJs in cell lines have yielded surprisingly heterogeneous mechanisms of dysfunction caused by various Cx m …
56 results